@article {Angeles-Han2088, author = {Sheila T. Angeles-Han and Christina F. Pelajo and Larry B. Vogler and Kelly Rouster-Stevens and Christine Kennedy and Lori Ponder and Courtney McCracken and Jorge Lopez-Benitez and Carolyn Drews-Botsch and Sampath Prahalad and The CARRA Registry Investigators}, editor = {Abramson, L. and Becker, M. and Beukelman, T. and Birmingham, J. and Blier, P. and Brown, A. and Chalom, E. and Dedeoglu, F. and Ferguson, P. and Goldsmith, D. and Gottlieb, B. and Graham, T. and Griffin, T. and Higgins, G. and Hollister, J.R. and Hsu, J. and Huttenlocher, A. and Ilowite, N. and Imundo, L. and Inman, C.J. and Jerath, R. and Jung, L. and Kahn, P. and Kingsbury, D. and Klein-Gitelman, M. and Lehman, T. and Lindsley, C. and McCurdy, D. and Moorthy, N. and Muscal, E. and Nater, M. and Olson, J. and O{\textquoteright}Neil, K. and Onel, K. and Prahalad, S. and Punaro, M. and Quintero, A. and Rabinovich, C. and Reed, A. and Ringold, S. and Robinson, A. and Rothman, D. and Ruth, N. and Schikler, K. and Sestak, A. and Singer, N. and Spalding, S. and Syed, R. and Szer, I. and Torok, K. and Vehe, R. and von Scheven, E. and Weiss, J. and Weiss, P. and White, A. and Yalcindag, A. and Zemel, L.}, title = {Risk Markers of Juvenile Idiopathic Arthritis-associated Uveitis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry}, volume = {40}, number = {12}, pages = {2088--2096}, year = {2013}, doi = {10.3899/jrheum.130302}, publisher = {The Journal of Rheumatology}, abstract = {Objective. To characterize the epidemiology and clinical course of children with juvenile idiopathic arthritis-associated uveitis (JIA-U) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and explore differences between African American (AA) and non-Hispanic white (NHW) children. Methods. There were 4983 children with JIA enrolled in the CARRA Registry. Of those, 3967 NHW and AA children were included in this study. Demographic and disease-related data were collected from diagnosis to enrollment. Children with JIA were compared to those with JIA-U. Children with JIA-U were also compared by race. Results. There were 459/3967 children (11.6\%) with JIA-U in our cohort with a mean age (SD) of 11.4 years ({\textpm} 4.5) at enrollment. Compared to children with JIA, they were younger at arthritis onset, more likely to be female, had \< 5 joints involved, had oligoarticular JIA, and were antinuclear antibody (ANA)-positive, rheumatoid factor (RF)-negative, and anticitrullinated protein antibody-negative. Predictors of uveitis development included female sex, early age of arthritis onset, and oligoarticular JIA. Polyarticular RF-positive JIA subtype was protective. Nearly 3\% of children with JIA-U were AA. However, of the 220 AA children with JIA, 6\% had uveitis; in contrast, 12\% of the 3721 NHW children with JIA had uveitis. Conclusion. In the CARRA registry, the prevalence of JIA-U in AA and NHW children is 11.6\%. We confirmed known uveitis risk markers (ANA positivity, younger age at arthritis onset, and oligoarticular JIA). We describe a decreased likelihood of uveitis in AA children and recommend further exploration of race as a risk factor in a larger population of AA children.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/40/12/2088}, eprint = {https://www.jrheum.org/content/40/12/2088.full.pdf}, journal = {The Journal of Rheumatology} }