TY - JOUR T1 - COMP-C3b Complexes in Rheumatoid Arthritis with Severe Extraarticular Manifestations JF - The Journal of Rheumatology JO - J Rheumatol SP - 2001 LP - 2005 DO - 10.3899/jrheum.130613 VL - 40 IS - 12 AU - Kaisa E. Happonen AU - Tore Saxne AU - Lennart Jacobsson AU - Gunnar Sturfelt AU - Johan Rönnelid AU - Tom Eirik Mollnes AU - Dick HeinegÄrd AU - Carl Turesson AU - Anna M. Blom Y1 - 2013/12/01 UR - http://www.jrheum.org/content/40/12/2001.abstract N2 - Objective. To investigate biomarker patterns in rheumatoid arthritis (RA) with extraarticular manifestations. Methods. Cartilage oligomeric matrix protein (COMP), COMP-C3b, and soluble terminal complement complexes (sTCC) were measured by ELISA. Results. COMP-C3b levels were higher in patients with RA than in healthy controls and lower in extraarticular RA (ExRA) than in RA controls. In patients with ExRA, sTCC levels were higher than in RA controls, and correlated inversely with serum COMP-C3b levels in the ExRA group. Conclusion. Patients with ExRA had lower levels of COMP-C3b. This may be a consequence of complement consumption or a lower potential for COMP from these patients to activate complement. ER -