TY - JOUR T1 - HLA-G 3′ Untranslated Region Polymorphisms Are Associated with Systemic Lupus Erythematosus in 2 Brazilian Populations JF - The Journal of Rheumatology JO - J Rheumatol SP - 1104 LP - 1113 DO - 10.3899/jrheum.120814 VL - 40 IS - 7 AU - Norma Lucena-Silva AU - Veridiana Sales Barbosa de Souza AU - Renan Garcia Gomes AU - Alex Fantinatti AU - Yara Costa Netto Muniz AU - Rafael Sales de Albuquerque AU - Alessandra Luna Ramos Monteiro AU - George Tadeu Nunes Diniz AU - Maria Rosângela Cunha Duarte Coelho AU - Celso Teixeira Mendes-Junior AU - Erick da Cruz Castelli AU - Eduardo Antônio Donadi Y1 - 2013/07/01 UR - http://www.jrheum.org/content/40/7/1104.abstract N2 - Objective. HLA-G has well recognized tolerogenic properties in physiological and nonphysiological conditions. The 3′ untranslated region (3′UTR) of the HLA-G gene has at least 3 polymorphic sites (14-bpINS/DEL, +3142C/G, and +3196C/G) described as associated with posttranscriptional influence on messenger RNA production; however, only the 14-bpINS/DEL and +3142C/G sites have been studied in systemic lupus erythematosus (SLE). Methods. We investigated the HLA-G 3′UTR polymorphic sites (14-bpINS/DEL, +3003C/T, +3010C/G, +3027A/C, +3035C/T, +3142C/G, +3187A/G, and +3196C/G) in 190 Brazilian patients with SLE and 282 healthy individuals in allele, genotype, and haplotype analyses. A multiple logistic regression model was used to assess the association of the disease features with the HLA-G 3′UTR haplotypes. Results. Increased frequencies were observed of the 14-bpINS (p = 0.053), +3010C (p = 0.008), +3142G (p = 0.006), and +3187A (p = 0.013) alleles, and increased frequencies of the 14-bpINS-INS (p = 0.094), +3010 C-C (p = 0.033), +3142 G-G (p = 0.021), and +3187 A-A (p = 0.035) genotypes. After Bonferroni correction, only the +3142G (p = 0.05) and +3010C (p = 0.06) alleles were overrepresented in SLE patients. The UTR-1 haplotype (14-bpDEL/+3003T/+3010G/+3027C/+3035C/+3142C/+3187G/+3196C) was underrepresented in SLE (pcorr = 0.035). Conclusion. These results indicate that HLA-G 3′UTR polymorphic sites, particularly +3142G and +3010C alleles, were associated with SLE susceptibility, whereas UTR-1 was associated with protection against development of SLE. ER -