TY - JOUR T1 - Outcome of Pregnancy in Italian Patients with Primary Sjögren Syndrome JF - The Journal of Rheumatology JO - J Rheumatol SP - 1143 LP - 1147 DO - 10.3899/jrheum.121518 VL - 40 IS - 7 AU - Roberta Priori AU - Angelica Gattamelata AU - Mariagrazia Modesti AU - Serena Colafrancesco AU - Silvia Frisenda AU - Antonina Minniti AU - Marialuisa Framarino-dei-Malatesta AU - Marta Maset AU - Luca Quartuccio AU - Salvatore De Vita AU - Elena Bartoloni AU - Alessia Alunno AU - Roberto Gerli AU - Francesca Strigini AU - Chiara Baldini AU - Chiara Tani AU - Marta Mosca AU - Stefano Bombardieri AU - Guido Valesini Y1 - 2013/07/01 UR - http://www.jrheum.org/content/40/7/1143.abstract N2 - Objective. To investigate pregnancy and fetal outcomes in patients with primary Sjögren syndrome (pSS). Methods. An obstetric history of 36 women with established diagnosis of pSS at pregnancy was obtained from a multicenter cohort of 1075 patients. In a subgroup case-control analysis, 12 deliveries in patients with pSS were compared with 96 control deliveries. Results. Thirty-six women (31 with anti-SSA/Ro and/or anti-SSB/La antibodies) with an established diagnosis of pSS had 45 pregnancies with the delivery of 40 newborns. Two miscarriages, 2 fetal deaths, and 1 induced abortion were recorded. Mean age at the first pregnancy was 33.9 years; mean number of pregnancies was 1.25; 18/40 (45%) cesarean births were delivered; mean pregnancy length was 38.5 weeks (range 32–43), with 6 preterm deliveries. The mean Apgar score at 5 min was 8.9, mean birthweight was 2920 g (range 826–4060 g). Congenital heart block (CHB) occurred in 2/40 (5%) newborns. The reported rate of breastfeeding for at least 1 month was 60.5%. In 4/40 pregnancies (10%) a flare of disease activity was observed within a year from delivery. In the case-control subgroup analysis, 12 deliveries were compared with 96 controls and no significant differences were found. Conclusion. Patients with pSS can have successful pregnancies, which might be followed by a mild relapse. CHB was the only cause of death for offspring of mothers with pSS. ER -