PT  - JOURNAL ARTICLE
AU  - Roberta Priori
AU  - Angelica Gattamelata
AU  - Mariagrazia Modesti
AU  - Serena Colafrancesco
AU  - Silvia Frisenda
AU  - Antonina Minniti
AU  - Marialuisa Framarino-dei-Malatesta
AU  - Marta Maset
AU  - Luca Quartuccio
AU  - Salvatore De Vita
AU  - Elena Bartoloni
AU  - Alessia Alunno
AU  - Roberto Gerli
AU  - Francesca Strigini
AU  - Chiara Baldini
AU  - Chiara Tani
AU  - Marta Mosca
AU  - Stefano Bombardieri
AU  - Guido Valesini
TI  - Outcome of Pregnancy in Italian Patients with Primary Sjögren Syndrome
AID  - 10.3899/jrheum.121518
DP  - 2013 Jul 01
TA  - The Journal of Rheumatology
PG  - 1143--1147
VI  - 40
IP  - 7
4099  - http://www.jrheum.org/content/40/7/1143.short
4100  - http://www.jrheum.org/content/40/7/1143.full
SO  - J Rheumatol2013 Jul 01; 40
AB  - Objective. To investigate pregnancy and fetal outcomes in patients with primary Sjögren syndrome (pSS). Methods. An obstetric history of 36 women with established diagnosis of pSS at pregnancy was obtained from a multicenter cohort of 1075 patients. In a subgroup case-control analysis, 12 deliveries in patients with pSS were compared with 96 control deliveries. Results. Thirty-six women (31 with anti-SSA/Ro and/or anti-SSB/La antibodies) with an established diagnosis of pSS had 45 pregnancies with the delivery of 40 newborns. Two miscarriages, 2 fetal deaths, and 1 induced abortion were recorded. Mean age at the first pregnancy was 33.9 years; mean number of pregnancies was 1.25; 18/40 (45%) cesarean births were delivered; mean pregnancy length was 38.5 weeks (range 32–43), with 6 preterm deliveries. The mean Apgar score at 5 min was 8.9, mean birthweight was 2920 g (range 826–4060 g). Congenital heart block (CHB) occurred in 2/40 (5%) newborns. The reported rate of breastfeeding for at least 1 month was 60.5%. In 4/40 pregnancies (10%) a flare of disease activity was observed within a year from delivery. In the case-control subgroup analysis, 12 deliveries were compared with 96 controls and no significant differences were found. Conclusion. Patients with pSS can have successful pregnancies, which might be followed by a mild relapse. CHB was the only cause of death for offspring of mothers with pSS.