RT Journal Article
SR Electronic
T1 Gastric Antral Vascular Ectasia and Its Clinical Correlates in Patients with Early Diffuse Systemic Sclerosis in the SCOT Trial
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 455
OP 460
DO 10.3899/jrheum.121087
VO 40
IS 4
A1 Hung, Emily W.
A1 Mayes, Maureen D.
A1 Sharif, Roozbeh
A1 Assassi, Shervin
A1 Machicao, Victor I.
A1 Hosing, Chitra
A1 St. Clair, E. William
A1 Furst, Daniel E.
A1 Khanna, Dinesh
A1 Forman, Stephen
A1 Mineishi, Shin
A1 Phillips, Kristine
A1 Seibold, James R.
A1 Bredeson, Christopher
A1 Csuka, Mary Ellen
A1 Nash, Richard A.
A1 Wener, Mark H.
A1 Simms, Robert
A1 Ballen, Karen
A1 Leclercq, Sharon
A1 Storek, Jan
A1 Goldmuntz, Ellen
A1 Welch, Beverly
A1 Keyes-Elstein, Lynette
A1 Castina, Sharon
A1 Crofford, Leslie J.
A1 Mcsweeney, Peter
A1 Sullivan, Keith M.
YR 2013
UL http://www.jrheum.org/content/40/4/455.abstract
AB Objective. To describe the prevalence and clinical correlates of endoscopic gastric antral vascular ectasia (GAVE; “watermelon stomach”) in early diffuse systemic sclerosis (SSc). Methods. Subjects with early, diffuse SSc and evidence of specific internal organ involvement were considered for the Scleroderma: Cyclophosphamide Or Transplant (SCOT) trial. In the screening procedures, all patients underwent upper gastrointestinal endoscopy. Patients were then categorized into those with or without endoscopic evidence of GAVE. Demographic data, clinical disease characteristics, and autoantibody data were compared using Pearson chi-square or Student t tests. Results. Twenty-three of 103 (22.3%) individuals were found to have GAVE on endoscopy. Although not statistically significant, anti-topoisomerase I (anti-Scl70) was detected less frequently among those with GAVE (18.8% vs 44.7%; p = 0.071). Similarly, anti-RNP antibodies (anti-U1 RNP) showed a trend to a negative association with GAVE (0 vs 18.4%; p = 0.066). There was no association between anti-RNA polymerase III and GAVE. Patients with GAVE had significantly more erythema or vascular ectasias in other parts of the stomach (26.1% vs 5.0%; p = 0.003). Conclusion. Endoscopic GAVE was present on screening in almost one-fourth of these highly selected patients with early and severe diffuse SSc. While anti-Scl70 and anti-U1 RNP trended toward a negative association with GAVE, there was no correlation between anti-RNA Pol III and GAVE. Patients with GAVE had a higher frequency of other gastric vascular ectasias outside the antrum, suggesting that GAVE may represent part of the spectrum of the vasculopathy in SSc.