RT Journal Article
SR Electronic
T1 Genetic Ancestry, Serum Interferon-α Activity, and Autoantibodies in Systemic Lupus Erythematosus
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1238
OP 1240
DO 10.3899/jrheum.111467
VO 39
IS 6
A1 KICHUL KO
A1 BEVERLY S. FRANEK
A1 MIRANDA MARION
A1 KENNETH M. KAUFMAN
A1 CARL D. LANGEFELD
A1 JOHN B. HARLEY
A1 TIMOTHY B. NIEWOLD
YR 2012
UL http://www.jrheum.org/content/39/6/1238.abstract
AB Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10−5). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α.