PT  - JOURNAL ARTICLE
AU  - KICHUL KO
AU  - BEVERLY S. FRANEK
AU  - MIRANDA MARION
AU  - KENNETH M. KAUFMAN
AU  - CARL D. LANGEFELD
AU  - JOHN B. HARLEY
AU  - TIMOTHY B. NIEWOLD
TI  - Genetic Ancestry, Serum Interferon-α Activity, and Autoantibodies in Systemic Lupus Erythematosus
AID  - 10.3899/jrheum.111467
DP  - 2012 Jun 01
TA  - The Journal of Rheumatology
PG  - 1238--1240
VI  - 39
IP  - 6
4099  - http://www.jrheum.org/content/39/6/1238.short
4100  - http://www.jrheum.org/content/39/6/1238.full
SO  - J Rheumatol2012 Jun 01; 39
AB  - Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10−5). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α.