RT Journal Article SR Electronic T1 Evaluation of a Shared Autoimmune Disease-associated Polymorphism of TRAF6 in Systemic Sclerosis and Giant Cell Arteritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1275 OP 1279 DO 10.3899/jrheum.120038 VO 39 IS 6 A1 F. DAVID CARMONA A1 AURORA SERRANO A1 LUIS RODRÍGUEZ-RODRÍGUEZ A1 JOSÉ LUIS CALLEJAS A1 CARMEN P. SIMEÓN A1 PATRICIA CARREIRA A1 SANTOS CASTAÑEDA A1 ROSER SOLANS A1 RICARDO BLANCO A1 The Spanish Scleroderma Group A1 The Spanish Giant Cell Arteritis Group A1 MIGUEL A. GONZÁLEZ-GAY A1 JAVIER MARTÍN YR 2012 UL http://www.jrheum.org/content/39/6/1275.abstract AB Objective. We evaluated whether a single-nucleotide polymorphism (SNP) of the TRAF6 gene previously associated with systemic lupus erythematosus and rheumatoid arthritis may be a common risk factor for systemic sclerosis (SSc) and giant cell arteritis (GCA). Methods. A total of 1185 patients with SSc, 479 patients with biopsy-proven GCA, and 1442 unrelated healthy controls of white Spanish origin were genotyped for the rs540386 variant using a specifically designed TaqMan© allele discrimination assay. Results. No significant associations of this SNP with global SSc or GCA were found. This was also the case when the potential associations of the TRAF6 polymorphism with the main clinical phenotypes of the 2 diseases (e.g., limited cutaneous and diffuse cutaneous SSc, or presence of polymyalgia rheumatica and visual ischemic manifestations in GCA) were assessed. Conclusion. Our data do not support a role of the rs540386 TRAF6 variant as a key component of the genetic network underlying SSc and GCA.