RT Journal Article
SR Electronic
T1 NPSR1 Gene Is Associated with Reduced Risk of Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1166
OP 1170
DO 10.3899/jrheum.111205
VO 39
IS 6
A1 GEMA ROBLEDO
A1 MIGUEL ANGEL GONZÁLEZ-GAY
A1 BENJAMÍN FERNÁNDEZ-GUTIÉRREZ
A1 JOSÉ RAMÓN LAMAS
A1 ALEJANDRO BALSA
A1 DORA PASCUAL-SALCEDO
A1 SANTOS CASTAÑEDA
A1 RICARDO BLANCO
A1 ISIDORO GONZÁLEZ-ALVARO
A1 ANTONIO GARCÍA
A1 ENRIQUE RAYA
A1 CARMEN GÓMEZ-VAQUERO
A1 MARIO DELGADO
A1 JAVIER MARTÍN
YR 2012
UL http://www.jrheum.org/content/39/6/1166.abstract
AB Objective. Neuropeptide S receptor 1 (NPSR1) is a G protein-coupled receptor involved in immune response and is associated with several inflammatory diseases. We investigated the possible contribution of several polymorphisms in the intronic region of NPSR1 to rheumatoid arthritis (RA). Methods. Genotyping of 7 single-nucleotide polymorphisms (SNP) was performed in a total of 1232 patients with RA and 983 healthy controls of Spanish white origin by real-time polymerase chain reaction technology, using the TaqMan 5′-allele discrimination assay. Results. One out of the 7 SNP analyzed (rs740347) was associated with RA [p after Bonferroni correction (pBNF) = 1.2 × 10−3, OR 0.73]. An association was also observed with rheumatoid factor-positive and shared epitope-positive RA (pBNF = 0.011, OR 0.73; pBNF = 0.037, OR 0.75, respectively). Conclusion. Our results show that variations in the NPSR1 intronic region are associated with low risk in patients with RA, supporting other evidence that this locus represents a common genetic factor in inflammatory diseases.