RT Journal Article
SR Electronic
T1 Invasive Fungal Infections in Patients with Systemic Lupus Erythematosus
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1814
OP 1818
DO 10.3899/jrheum.111498
VO 39
IS 9
A1 MARCO ULISES MARTÍNEZ-MARTÍNEZ
A1 DAVID HERRERA-VAN OOSTDAM
A1 SUSANA ROMÁN-ACOSTA
A1 MARTÍN MAGAÑA-AQUINO
A1 LOURDES BARANDA-CÁNDIDO
A1 CARLOS ABUD-MENDOZA
YR 2012
UL http://www.jrheum.org/content/39/9/1814.abstract
AB Objective. Invasive fungal infections (IFI) are catastrophic diseases associated with a high mortality. Relatively few cases of IFI have been described in systemic lupus erythematosus (SLE) and their related factors have not been completely explored. We evaluated factors associated with IFI in patients with SLE. Methods. All patients with both IFI and SLE admitted to our hospital in the last 7 years were evaluated and each was compared with 5 hospitalized patients with SLE (controls). Demographic factors, duration of SLE, and treatment in the previous month were compared. Results. Sixty patients with SLE were evaluated (10 with IFI and 50 controls). Median age was 29 years. High C-reactive protein levels were associated with IFI, along with other factors such as high disease activity, mechanical ventilation, treatment with antibiotics, hemodialysis, high doses of glucocorticoids (GC), and treatment with mycophenolate mofetil. Mortality was 4 times more frequent in patients with IFI than in SLE patients without the deep fungal infection. Conclusion. IFI is a rare infection observed in patients with rheumatic diseases. We describe factors associated with IFI in patients with SLE. IFI is associated with elevated morbidity and mortality. Early diagnosis and treatment are desirable.