<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">GLADMAN, DAFNA D.</style></author><author><style face="normal" font="default" size="100%">UROWITZ, MURRAY B.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">University of Toronto Lupus Clinic Turns 40</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of Rheumatology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2012-05-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1074-1077</style></pages><doi><style  face="normal" font="default" size="100%">10.3899/jrheum.111581</style></doi><volume><style face="normal" font="default" size="100%">39</style></volume><issue><style face="normal" font="default" size="100%">5</style></issue><abstract><style  face="normal" font="default" size="100%">The University of Toronto Lupus Clinic at the Toronto Western Hospital celebrated its 40th anniversary April 2, 2011. Great cause for celebration, particularly, since more than 1600 patients have been registered in what is one of the largest databases of lupus patients in the world — probably the only one following patients prospectively according to a standard protocol since 1970 — it was also an opportunity to pay tribute to Dr. Murray Urowitz, founder and director of the clinic, and to his contributions to lupus care and research.This milestone celebration took the form of a symposium, held April 2, 2011; several current and previous trainees were invited to give oral presentations on their current work as it relates to their training at the Lupus Clinic, while others submitted abstracts for poster presentations. By way of introduction, Dafna Gladman reviewed the achievements of the University of Toronto Lupus Clinic since its inception. Murray Urowitz began the Lupus Clinic in 1970 to study the correlation between clinical and serological activity in systemic lupus erythematosus (SLE). A standardized data retrieval form was developed including demographic features, disease-related features, and laboratory tests and therapies. Of note, there was no computer! Despite the lack of computer assistance, several seminal observations were made. These include the bimodal mortality pattern of SLE and the recognition that patients with SLE were at risk for accelerated atherosclerosis1. The impact of disease and comorbidities in the first 110 patients registered at the clinic were then highlighted2. A new observation of nail lesions in SLE was described3. By 1977, it became clear that computerization of the data would greatly facilitate research. During the first phase data were entered on the University of Toronto mainframe computer using punch cards. In 1980 the first desktop computer …</style></abstract></record></records></xml>