RT Journal Article
SR Electronic
T1 A Nonsynonymous Functional Variant of the <em>ITGAM</em> Gene Is Not Involved in Biopsy-proven Giant Cell Arteritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2598
OP 2601
DO 10.3899/jrheum.110685
VO 38
IS 12
A1 F. DAVID CARMONA
A1 AURORA SERRANO
A1 LUIS RODRÍGUEZ-RODRÍGUEZ
A1 SANTOS CASTAÑEDA
A1 JOSÉ A. MIRANDA-FILLOY
A1 INMACULADA C. MORADO
A1 JAVIER NARVÁEZ
A1 ROSER SOLANS
A1 BERNARDO SOPEÑA
A1 BEGOÑA MARÍ-ALFONSO
A1 AINHOA UNZURRUNZAGA
A1 NORBERTO ORTEGO-CENTENO
A1 RICARDO BLANCO
A1 EUGENIO DE MIGUEL
A1 ANA HIDALGO-CONDE
A1 JAVIER MARTÍN
A1 MIGUEL A. GONZÁLEZ-GAY
YR 2011
UL http://www.jrheum.org/content/38/12/2598.abstract
AB Objective. To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA). Methods. A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology. Results. No association was observed between ITGAM rs1143679 and GCA (p = 0.80, OR 0.97). Similarly, subphenotype analyses did not yield significant differences between the case subgroups and the control set or between GCA patients with or without the main specific features of GCA. Conclusion. Our results suggest that the ITGAM rs1143679 variant does not play an important role in the pathophysiology of GCA.