PT  - JOURNAL ARTICLE
AU  - VIRGINIA RUIZ-ESQUIDE
AU  - JOSÉ A. GÓMEZ-PUERTA
AU  - JUAN D. CAÑETE
AU  - EDUARD GRAELL
AU  - IVONNE VAZQUEZ
AU  - M. GUADALUPE ERCILLA
AU  - ODETTE VIÑAS
AU  - ANTONIO GÓMEZ-CENTENO
AU  - ISABEL HARO
AU  - RAIMON SANMARTÍ
TI  - Effects of Smoking on Disease Activity and Radiographic Progression in Early Rheumatoid Arthritis
AID  - 10.3899/jrheum.110410
DP  - 2011 Dec 01
TA  - The Journal of Rheumatology
PG  - 2536--2539
VI  - 38
IP  - 12
4099  - http://www.jrheum.org/content/38/12/2536.short
4100  - http://www.jrheum.org/content/38/12/2536.full
SO  - J Rheumatol2011 Dec 01; 38
AB  - Objective. To analyze the effects of cigarette smoking on disease activity and radiographic damage in patients with early rheumatoid arthritis (RA). Methods. Study subjects were 156 patients with early RA (< 2 yrs). Disease activity, therapeutic response, and radiographic progression were compared in smokers and nonsmokers at 24 months. Results. At baseline, ever-smokers had earlier disease onset and a closer association with the shared epitope (SE), but not more seropositive disease. No significant differences were observed in disease activity and European League Against Rheumatism therapeutic responses between smokers and nonsmokers. Multivariate analysis showed that baseline Larsen score, the HLA-DRB*04 genotype, being female, and current smoking were associated with radiographic progression. Conclusion. In patients with early RA, smoking was associated with earlier disease onset and the SE. Smoking was an independent factor of radiographic progression.