RT Journal Article
SR Electronic
T1 High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 979
OP 982
DO 10.3899/jrheum.101261
VO 38
IS 6
A1 FLEUR AUBART
A1 BRUNO CRESTANI
A1 PASCALE NICAISE-ROLAND
A1 FLORENCE TUBACH
A1 CAROLINE BOLLET
A1 KAREN DAWIDOWICZ
A1 EMILIE QUINTIN
A1 GILLES HAYEM
A1 ELISABETH PALAZZO
A1 OLIVIER MEYER
A1 SYLVIE CHOLLET-MARTIN
A1 PHILIPPE DIEUDÉ
YR 2011
UL http://www.jrheum.org/content/38/6/979.abstract
AB Objective. To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases. Methods. A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease. Results. Male sex (OR 3.29, 95% CI 1.59–6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25–1.78) were identified as independent risk factors for lung disease in the RA population. Conclusion. High anti-CCP2 levels are associated with lung disease in the RA population.