RT Journal Article
SR Electronic
T1 Prevalence of and Factors Associated with Hypertension in Young and Old Women with Systemic Lupus Erythematosus
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1026
OP 1032
DO 10.3899/jrheum.101132
VO 38
IS 6
A1 JOSÉ MARIO SABIO
A1 JOSÉ ANTONIO VARGAS-HITOS
A1 NURIA NAVARRETE-NAVARRETE
A1 JUAN DIEGO MEDIAVILLA
A1 JUAN JIMÉNEZ-JÁIMEZ
A1 ANTONIO DÍAZ-CHAMORRO
A1 JUAN JIMÉNEZ-ALONSO
YR 2011
UL http://www.jrheum.org/content/38/6/1026.abstract
AB Objective. Hypertension (HT) is more prevalent in patients with systemic lupus erythematosus (SLE) than among the general population and it has been associated with atherosclerotic cardiovascular diseases in these patients. We examined the proportion of HT and factors associated with it in young and old women with SLE. Methods. Participants (112 women with SLE and 223 healthy age-matched women) were categorized as young (age ≤ 40 years) or old (age > 40 years). We compared cardiovascular and specific SLE-related variables and inflammatory markers in hypertensive and normotensive women with SLE for each age range. We also assessed the factors independently associated with HT in the entire cohort and in each age range by means of a multivariate regression analysis. Results. The prevalence of HT was higher in women with SLE than in controls (56% vs 29%; p < 0.001), and was proportionally higher in younger women with SLE (40% vs 11%; p < 0.001) than in older women with SLE (74% vs 47%; p = 0.001). After adjustment for potential confounders, HT was associated with renal involvement and higher nonobesity-related insulin levels in younger women with SLE. In older patients, HT was associated with age, renal involvement, and obesity. Finally, in the entire cohort, HT was associated with age, insulin, renal involvement, and the Systemic Lupus Erythematosus Disease Activity Index score. Conclusion. An association between HT and insulin has been identified in women with SLE, particularly younger ones. Factors associated with HT in women with SLE differed depending on their age. HT was more prevalent in women with SLE than in control subjects, being proportionally higher in young women with SLE.