PT  - JOURNAL ARTICLE
AU  - ANNU NÄKKI
AU  - TAPIO VIDEMAN
AU  - URHO M. KUJALA
AU  - MATTI SUHONEN
AU  - MINNA MÄNNIKKÖ
AU  - LEENA PELTONEN
AU  - MICHELE C. BATTIÉ
AU  - JAAKKO KAPRIO
AU  - JANNA SAARELA
TI  - Candidate Gene Association Study of Magnetic Resonance Imaging-based Hip Osteoarthritis (OA): Evidence for <em>COL9A2</em> Gene as a Common Predisposing Factor for Hip OA and Lumbar Disc Degeneration
AID  - 10.3899/jrheum.100080
DP  - 2011 Apr 01
TA  - The Journal of Rheumatology
PG  - 747--752
VI  - 38
IP  - 4
4099  - http://www.jrheum.org/content/38/4/747.short
4100  - http://www.jrheum.org/content/38/4/747.full
SO  - J Rheumatol2011 Apr 01; 38
AB  - Objective. To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA). Methods. Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed. Results. Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA. Conclusion. The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases.