@article {N{\"A}KKI747, author = {ANNU N{\"A}KKI and TAPIO VIDEMAN and URHO M. KUJALA and MATTI SUHONEN and MINNA M{\"A}NNIKK{\"O} and LEENA PELTONEN and MICHELE C. BATTI{\'E} and JAAKKO KAPRIO and JANNA SAARELA}, title = {Candidate Gene Association Study of Magnetic Resonance Imaging-based Hip Osteoarthritis (OA): Evidence for COL9A2 Gene as a Common Predisposing Factor for Hip OA and Lumbar Disc Degeneration}, volume = {38}, number = {4}, pages = {747--752}, year = {2011}, doi = {10.3899/jrheum.100080}, publisher = {The Journal of Rheumatology}, abstract = {Objective. To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA). Methods. Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed. Results. Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA. Conclusion. The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/38/4/747}, eprint = {https://www.jrheum.org/content/38/4/747.full.pdf}, journal = {The Journal of Rheumatology} }