RT Journal Article
SR Electronic
T1 Nonsteroidal Antiinflammatory Drug Withdrawal in Patients with Stable Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2150
OP 2152
DO 10.3899/jrheum.101162
VO 38
IS 10
A1 GAYLE E. McKELLAR
A1 ROSEMARY HAMPSON
A1 ANN TIERNEY
A1 HILARY A. CAPELL
A1 RAJAN MADHOK
YR 2011
UL http://www.jrheum.org/content/38/10/2150.abstract
AB Objective. To evaluate the effect of nonsteroidal antiinflammatory drug (NSAID) withdrawal on blood pressure (BP), 44-joint Disease Activity Score (DAS44), and functional assessments in patients with stable rheumatoid arthritis (RA). Methods. NSAID was withdrawn from 30 patients with stable RA (DAS44 ≤ 2.8). Other prescribed medication continued. Clinical and laboratory measures were taken at baseline, 6 weeks, and 12 weeks. Results. No participants required NSAID reintroduction during the study period. Significant improvement in systolic BP was noted: maximal median reduction was 7 mm Hg (baseline to 12 weeks). There was no significant deterioration in DAS44 or function. Eleven participants required additional intervention. Conclusion. NSAID withdrawal resulted in improvement in BP without loss of disease control.