RT Journal Article SR Electronic T1 Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 2045 OP 2050 DO 10.3899/jrheum.110422 VO 38 IS 9 A1 MIKKEL ØSTERGAARD A1 PERNILLE BØYESEN A1 IRIS ESHED A1 FRÉDÉRIQUE GANDJBAKHCH A1 SIRI LILLEGRAVEN A1 PAUL BIRD A1 VIOLAINE FOLTZ A1 ANNELIES BOONEN A1 MARISSA LASSERE A1 KAY-GEERT HERMANN A1 ALLEN ANANDARAJAH A1 UFFE MØLLER DØHN A1 JANE FREESTON A1 CHARLES G. PETERFY A1 HARRY K. GENANT A1 ESPEN A. HAAVARDSHOLM A1 FIONA M. McQUEEN A1 PHILIP G. CONAGHAN YR 2011 UL http://www.jrheum.org/content/38/9/2045.abstract AB Objective. To develop and validate a magnetic resonance imaging (MRI) method of assessment of joint space narrowing (JSN) in rheumatoid arthritis (RA). Methods. Phase A: JSN was scored 0–4 on MR images of 5 RA patients and 3 controls at 15 wrist sites and 2nd–5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using a preliminary scoring system. Phase B: Image review, discussion, and consensus on JSN definition, and revised scoring system. Phase C: MR images of 15 RA patients and 4 controls were scored using revised system by 5 readers (4 once, one twice), and results compared with radiographs [Sharp-van der Heijde (SvdH) method]. Results. Phase A: Intraobserver agreement: intraclass correlation coefficient (ICC) = 0.99; smallest detectable difference (SDD, for mean of readings) = 2.8 JSN units (4.9% of observed maximal score). Interobserver agreement: ICC = 0.93; SDD = 6.4 JSN units (9.9%). Phase B: Agreement was reached on JSN definition (reduced joint space width compared to normal, as assessed in a slice perpendicular to the joint surface), and revised scoring system (0–4 at 17 wrist sites and 2nd–5th MCP; 0: none; 1: 1–33%; 2: 34–66%; 3: 67–99%; 4: ankylosis). Phase C: Intraobserver agreement: ICC = 0.90; SDD = 6.8 JSN units (11.0%). Interobserver agreement: ICC = 0.92 and SDD = 6.2 JSN units (8.7%). The correlation (ICC) with the SvdH radiographic JSN score of the wrist/hand was 0.77. Simplified approaches evaluating fewer joint spaces demonstrated similar reliability and correlation with radiographic scores. Conclusion. An MRI scoring system of JSN in RA wrist and MCP joints was developed and showed construct validity and good intra- and interreader agreements. The system may, after further validation in longitudinal data sets, be useful as an outcome measure in RA.