RT Journal Article
SR Electronic
T1 The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1871
OP 1874
DO 10.3899/jrheum.101316
VO 38
IS 9
A1 HUBERTINA J.M.J. CRIJNS
A1 JANNEKE JENTINK
A1 ESTER GARNE
A1 CHRISTINE C. GISPEN-de WIED
A1 SABINE M.J.M. STRAUS
A1 LOLKJE T.W. de JONG-van den BERG
YR 2011
UL http://www.jrheum.org/content/38/9/1871.abstract
AB Objective. To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-α (TNF-α) antagonist and the general population. Methods. Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database. Results. Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-α antagonist exposure, so comparison of proportions was imprecise. Only the category “limb abnormalities” showed a significantly higher proportion in the general population. Conclusion. The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-α antagonists could not be confirmed using a population-based congenital anomaly database.