RT Journal Article SR Electronic T1 Healthcare Cost and Loss of Productivity in a Canadian Population of Patients with and without Lupus Nephritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 658 OP 666 DO 10.3899/jrheum.100482 VO 38 IS 4 A1 ELAHEH AGHDASSI A1 WENDY ZHANG A1 YVAN ST-PIERRE A1 ANN E. CLARKE A1 STACEY MORRISON A1 VALENTINA PEEVA A1 CAROLINA LANDOLT-MARTICORENA A1 JIANDONG SU A1 HEATHER REICH A1 JAMES SCHOLEY A1 ANDREW HERZENBERG A1 JANET E. POPE A1 CHRISTINE PESCHKEN A1 LuNNET CaNIOS Investigators A1 JOAN E. WITHER A1 PAUL R. FORTIN YR 2011 UL http://www.jrheum.org/content/38/4/658.abstract AB Objective. To compare the healthcare cost and loss of productivity in patients with systemic lupus erythematosus (SLE) with (LN) and without lupus nephritis (lupus nephritis-negative, LNN). Method. Patients were classified into those with active (ALN and ALNN) and inactive disease (ILN and ILNN). Patients reported on visits to healthcare professionals and use of diagnostic tests, medications, assistive devices, alternative treatments, hospital emergency visits, surgical procedures, and hospitalizations as well as loss of productivity in the 4 weeks preceding enrollment. Results. Enrollment was 141 patients, 79 with LN and 62 LNN. Patients with LN were more likely to visit rheumatologists and nephrologists, undergo diagnostic tests, and had higher costs for medications than patients who were LNN. The annual healthcare cost averaged $CAN 12,597 ± 9946 for patients with LN and $10,585 ± 13,149 for patients who were LNN, a difference of $2012 (95% CI –$2075, $6100). Patients with ALN had more diagnostic tests and surgical procedures, contributing to a significantly higher annual direct cost ($14,224 ± 10,265) compared to patients with ILN ($9142 ± 8419) and a difference of $5082 (95% CI $591, $9573). The healthcare cost was not different between patients with ALNN and patients with ILNN. In patients with LN and patients who were LNN, < 50% were employed and on average missed 6.5–9 days of work per month. The loss of productivity was significantly higher for caregivers of patients with LN than caregivers of patients who were LNN. Conclusion. Healthcare cost and loss of productivity were similar between patients with LN and patients who were LNN; the loss of productivity for caregivers is higher for patients with LN; and the healthcare cost is greater in ALN than in ILN.