PT  - JOURNAL ARTICLE
AU  - SO-YOUNG BANG
AU  - TAE-HWAN KIM
AU  - BITNARA LEE
AU  - EUNJI KWON
AU  - SANG HYUN CHOI
AU  - KI SOO LEE
AU  - SEUNG CHEOL SHIM
AU  - ANGELA POPE
AU  - PROTON RAHMAN
AU  - JOHN D. REVEILLE
AU  - ROBERT D. INMAN
TI  - Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with <em>ERAP1</em> and 2p15 Reported in White Patients
AID  - 10.3899/jrheum.100652
DP  - 2011 Feb 01
TA  - The Journal of Rheumatology
PG  - 322--324
VI  - 38
IP  - 2
4099  - http://www.jrheum.org/content/38/2/322.short
4100  - http://www.jrheum.org/content/38/2/322.full
SO  - J Rheumatol2011 Feb 01; 38
AB  - Objective. Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22. We evaluated these new candidate genes in a large cohort of Korean patients with AS. Methods. A group of 1164 patients with AS and 752 healthy controls were enrolled for our study. Eight single-nucleotide polymorphisms (SNP) were analyzed to define genetic association with AS by MassARRAY system. Results. Significant positive associations of AS with endoplasmic reticulum aminopeptidase 1 SNP, rs27037 (p = 1.31 × 10−4), and rs27434 (p = 4.59 × 10−6), were observed. The rs10865331 of gene desert at 2p15 also showed a significant association with AS (p = 4.63 × 10−5). Conclusion. This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS.