RT Journal Article
SR Electronic
T1 Endothelial Progenitor Cells in Mixed Cryoglobulinemia
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1505
OP 1507
DO 10.3899/jrheum.100012
VO 37
IS 7
A1 FRANCESCO MARCHI
A1 DANIELE CHIMENTI
A1 ANTONIO TAVONI
A1 ALESSANDRA DELLA ROSSA
A1 STEFANO BOMBARDIERI
A1 PAOLA MIGLIORINI
YR 2010
UL http://www.jrheum.org/content/37/7/1505.abstract
AB Objective. Endothelial progenitor cells (EPC) are a rare population of circulating cells involved in vascular homeostasis. Our aim was to analyze EPC in patients with mixed cryoglobulinemia (MC). Methods. EPC were evaluated by cytometry according to guidelines of the International Society for Hematotherapy and Graft Engineering in 17 patients with MC and 36 controls. Results. Numbers of EPC were significantly increased in MC compared to controls and correlated with cryocrit, but not with clinical manifestations of the disease. Conclusion. The high number of EPC might indicate an intact vascular repair ability. Alternatively, EPC might be defective in homing ability and their increase may represent the attempt to restore vascular integrity.