TY - JOUR T1 - Healing of Erosive Disease in Multicentric Reticulohistiocytosis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1366 LP - 1367 DO - 10.3899/jrheum.091329 VL - 37 IS - 6 AU - AARON W. BROADWELL AU - KENNETH T. CALAMIA AU - MARK J. KRANSDORF AU - WILLIAM W. GINSBURG Y1 - 2010/06/01 UR - http://www.jrheum.org/content/37/6/1366.abstract N2 - To the Editor:Multicentric reticulohistiocytosis (MRH) is a rare multisystem disease reported to respond to various regimens including prednisone, methotrexate (MTX), cyclophosphamide, and other immunosuppressants. We previously described a 55-year-old man with MRH followed at our institution for 9 years. He responded to treatment with etanercept, leflunomide, and prednisone1. Over the past 5 years since that report, the patient has remained in remission, and followup radiographs demonstrated significant healing of erosions in his hands. Prior to the initial visit at our institution he had been treated with MTX, hydroxychloroquine, prednisone, and chlorambucil with prednisone, with no improvement after 4 months. He had also been treated with alendronate 70 mg/week for osteoporosis prophylaxis. At his initial evaluation, he was taking 40 mg/day prednisone and 25 mg/week MTX. He had active polyarthritis and multiple skin lesions. Cyclophosphamide was added at 2 mg/kg. He had gradual improvement of skin lesions and arthritis over 8 months, and prednisone was reduced to 20 mg/day. Cyclophosphamide was discontinued due to gross hematuria. Etanercept 25 mg … ER -