RT Journal Article
SR Electronic
T1 Undifferentiated Spondyloarthritis: A Longterm Followup
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1195
OP 1199
DO 10.3899/jrheum.090625
VO 37
IS 6
A1 SAMPAIO-BARROS, PERCIVAL D.
A1 BORTOLUZZO, ADRIANA B.
A1 CONDE, ROSENEIDE A.
A1 COSTALLAT, LILIAN TEREZA L.
A1 SAMARA, ADIL M.
A1 BÉRTOLO, MANOEL B.
YR 2010
UL http://www.jrheum.org/content/37/6/1195.abstract
AB Objective. To analyze the longterm followup of a series of Brazilian patients with undifferentiated spondyloarthritis (uSpA). Methods. Prospective study analyzing a group of 111 patients with the diagnosis of uSpA, fulfilling the European Spondylarthropathy Study Group and the Amor criteria, who were followed for 5 to 10 years in a single university referral center. Patients had their outcome analyzed at 5, 7, and 10 years. Results. There was a predominance of men (81.1%), white ethnicity (78.4%), and positive HLA-B27 (61.3%), with a mean age at onset of 27.2 years. Twenty-seven patients presented development to ankylosing spondylitis (AS; 24.3%) and 3 to psoriatic arthritis (PsA; 2.7%), while 25 patients (22.5%) went into remission during the followup. Univariate logistic regression analysis revealed that ethnicity, HLA-B27, buttock pain, inflammatory low back pain, ankle involvement, grade I sacroiliitis at the beginning of the study, and the use of sulfasalazine were statistically associated with progression to AS. Multivariate logistic regression analysis revealed that HLA-B27 (p = 0.035, OR 6.720, 95% CI 11.45–39.43) and buttock pain (p = 0.009, OR 6.211, 95% CI 1.591–24.25) were statistically associated with progression to AS. Conclusion. In a longterm followup of 111 Brazilian patients with uSpA, HLA-B27 and buttock pain were significant predictors of progression to a definite disease.