RT Journal Article
SR Electronic
T1 More Night Than Day — Circadian Rhythms in Polymyalgia Rheumatica and Ankylosing Spondylitis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 894
OP 899
DO 10.3899/jrheum.091283
VO 37
IS 5
A1 CORNELIA M. SPIES
A1 MAURIZIO CUTOLO
A1 RAINER H. STRAUB
A1 GERD-RÜDIGER BURMESTER
A1 FRANK BUTTGEREIT
YR 2010
UL http://www.jrheum.org/content/37/5/894.abstract
AB The circadian rhythm of symptoms in patients with chronic inflammatory diseases is well known. Circadian rhythms could be used to identify targets for time-adapted antiinflammatory therapies, which are administered prior to the flare of cytokine synthesis and inflammatory activity. In recent years, the diurnal variations in rheumatoid arthritis have been described precisely for pain, stiffness, and functional disability, as well as the underlying cyclic variations in hormone levels and cytokine concentrations. This review summarizes the current knowledge on circadian rhythms in other rheumatic diseases, focusing on polymyalgia rheumatica and ankylosing spondylitis.