RT Journal Article SR Electronic T1 Influence of STAT4 Polymorphism in Primary Sjögren’s Syndrome JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1016 OP 1019 DO 10.3899/jrheum.091007 VO 37 IS 5 A1 ROGELIO J. PALOMINO-MORALES A1 LINA-MARCELA DIAZ-GALLO A1 TORSTEN WITTE A1 JUAN-MANUEL ANAYA A1 JAVIER MARTÍN YR 2010 UL http://www.jrheum.org/content/37/5/1016.abstract AB Objective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren’s syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82–1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96–2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 × 10−6, OR 1.40, 95% CI 1.21–1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene.