RT Journal Article SR Electronic T1 Delayed Clinical Response in Patients with Juvenile Idiopathic Arthritis Treated with Etanercept JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 665 OP 667 DO 10.3899/jrheum.090550 VO 37 IS 3 A1 MARIEKE H. OTTEN A1 FEMKE H.M. PRINCE A1 MARINKA TWILT A1 MARION A.J. van ROSSUM A1 WINEKE ARMBRUST A1 ESTHER P.A.H. HOPPENREIJS A1 SYLVIA KAMPHUIS A1 YVONNE KOOPMAN-KEEMINK A1 NICO M. WULFFRAAT A1 SIMONE L. GORTER A1 REBECCA ten CATE A1 LISETTE W.A. van SUIJLEKOM-SMIT YR 2010 UL http://www.jrheum.org/content/37/3/665.abstract AB Objective. To evaluate response in patients with juvenile idiopathic arthritis (JIA) who failed to meet response criteria after 3 months of etanercept treatment. Methods. This was a prospective ongoing multicenter observational study of all Dutch patients with JIA using etanercept. Response according to American College of Rheumatology Pediatric 30 criteria was assessed at study start and at 3 and 15 months. Results. In total we studied 179 patients of median age 5.8 years at disease onset; 70% were female. Thirty-four patients did not respond after 3 months, of which 20 continued etanercept and 11 achieved response thereafter. Conclusion. The delayed clinically relevant response in a substantial proportion of patients who initially did not respond justifies the consideration of continuing therapy to at least 6 months.