TY - JOUR T1 - Scoring Adult-onset Still’s Disease JF - The Journal of Rheumatology JO - J Rheumatol SP - 2203 LP - 2204 DO - 10.3899/jrheum.100783 VL - 37 IS - 11 AU - RUEDIGER B. MUELLER AU - AHMED SHERIFF Y1 - 2010/11/01 UR - http://www.jrheum.org/content/37/11/2203.abstract N2 - Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease of uncertain etiology. Patients with AOSD develop a combination of several disease manifestations. Some of these disease manifestations are arthritis, fever, leukocytosis, and evanescent rash. But, in parallel, various systemic manifestations such as splenomegaly and pneumonitis, among others, may occur.The diagnosis of AOSD is problematic, because no single diagnostic test or characteristic histopathology exists. Patients sometimes suffer from delays in diagnosis including protracted efforts to exclude occult infection or neoplasm because AOSD is a rare diagnosis, and differential diagnoses must be excluded. The clinician should consider AOSD in the evaluation of undiagnosed fever of unknown origin, particularly if present in association with rheumatic complaints1.More than 99% of patients with AOSD manifest with fever > 39°C at some time during the course of their disease2. Most common is a high-spiking, once per day fever. Low-grade or atypical fever patterns are sometimes encountered in older patients (> 35 … Address correspondence to Dr. Sheriff. E-mail: Ahmed.Sheriff{at}charite.de ER -