RT Journal Article SR Electronic T1 OARSI/OMERACT Criteria of Being Considered a Candidate for Total Joint Replacement in Knee/Hip Osteoarthritis as an Endpoint in Clinical Trials Evaluating Potential Disease Modifying Osteoarthritic Drugs JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 2097 OP 2099 DO 10.3899/jrheum.090365 VO 36 IS 9 A1 MAXIME DOUGADOS A1 GILLIAN HAWKER A1 STEFAN LOHMANDER A1 AILEEN M. DAVIS A1 PAUL DIEPPE A1 JEAN-FRANCIS MAILLEFERT A1 LAURE GOSSEC YR 2009 UL http://www.jrheum.org/content/36/9/2097.abstract AB Objective. A disease-modifying osteoarthritic drug (DMOAD) should interfere with the cartilage breakdown observed and improve symptoms or prevent deterioration of the patient’s clinical condition. We propose a composite index including structural and symptomatic variables of osteoarthritis (OA) as criteria for being considered a candidate for total joint replacement as an endpoint in clinical trials evaluating potential DMOAD. Methods. An OARSI/OMERACT task force conducted this study in 3 steps: (1) The 3 main domains — pain, function, structure — were revisited; (2) For each of the domains a “non-acceptable state” and a “relevant” progression for their structure were defined; and (3) a set of criteria was proposed combining the information from these 3 domains. Results. A questionnaire was elaborated for the domains “pain” and “function.” Systematic research of the literature and evaluation of different databases concluded that the domain “structure” should be evaluated by radiological joint space width in millimeters. An unacceptable radiographic progression was defined as a change in the joint space width over the measurement error. An international, cross-sectional study is proposing a definition of a “nonacceptable symptom state.” Conclusion. The objective of the ongoing OARSI/OMERACT initiative is to propose criteria for being considered a candidate for total joint replacement to be used as an endpoint in clinical trials evaluating potential DMOAD. The preliminary steps of this initiative have been completed.