TY - JOUR T1 - Prevalence of Autoantibodies in SAPHO Syndrome: A Single-center Study of 90 Patients JF - The Journal of Rheumatology JO - J Rheumatol SP - 639 LP - 643 DO - 10.3899/jrheum.090863 VL - 37 IS - 3 AU - CÉLINE GROSJEAN AU - MARGARITA HURTADO-NEDELEC AU - PASCALE NICAISE-ROLAND AU - RODRIGO FERREYRA-DILLON AU - CAROLINE BOLLET AU - EMILIE QUINTIN AU - PHILIPPE DIEUDE AU - ELISABETH PALAZZO AU - MARIE-JOSÉ WATTIAUX AU - MARCEL-FRANCIS KAHN AU - OLIVIER MEYER AU - SYLVIE CHOLLET-MARTIN AU - GILLES HAYEM Y1 - 2010/03/01 UR - http://www.jrheum.org/content/37/3/639.abstract N2 - Objective. To determine the prevalence of the most often tested autoantibodies in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Methods. We identified 90 patients seen in our unit between June 2002 and June 2009, and diagnosed according to the proposed criteria for SAPHO syndrome. Demographic and clinical data were collected as well as immunological results, including antinuclear, antithyroid peroxydase (TPO), antithyroid globulin (Tg), antigastric parietal cell, antismooth muscle, antimitochondria, and anti-liver-kidney microsome (LKM) antibodies. Anticyclic citrullinated peptide (CCP) antibodies were analyzed in 69 patients, antibodies to soluble extractable nuclear antigens in 43, anti-double-stranded DNA (dsDNA) antibodies in 22 [depending on the type of fluorescence of antinuclear antibody (ANA)], and antiendomysium antibodies in 55. Results Autoantibodies were found in 20 patients (22.2%): 14 patients (15.5%) had positive ANA (titer ≥ 1/160); among them, 10 (11%) patients never took a lupus-inducing drug. Antithyroid antibodies (anti-TPO and/or anti-Tg antibodies) were found in only 3 patients (3.3%). Three patients (3.3%) were positive for antigastric parietal cell antibodies and 4 (4.4%) were weakly positive for antismooth muscle antibodies. Antimitochondria and LKM antibodies were negative in all 90 patients. Anti-CCP and anti-dsDNA antibodies were negative in the 69 and 22 patients tested, respectively. One out of 43 patients (2.3%) had anti-SSA antibodies. Antiendomysium antibodies were negative in the 55 patients tested. Conclusion. Our study indicates an increased prevalence of autoantibodies in SAPHO syndrome, with no specific profile. We failed to confirm the reports of an increased prevalence of antithyroid antibodies. These results tend to support a link between autoimmunity and SAPHO syndrome. ER -