RT Journal Article SR Electronic T1 Trp64Arg Polymorphism of the ADRB3 Gene Predicts Hyperuricemia Risk in a Population from Southern Spain JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 417 OP 421 DO 10.3899/jrheum.090637 VO 37 IS 2 A1 SONSOLES MORCILLO A1 GEMMA ROJO-MARTÍNEZ A1 GRACIA MARÍA MARTÍN-NÚÑEZ A1 JUAN MIGUEL GÓMEZ-ZUMAQUERO A1 EDUARDO GARCÍA-FUENTES A1 MARISOL RUIZ de ADANA A1 MARÍA de la CRUZ ALMARAZ A1 FEDERICO SORIGUER YR 2010 UL http://www.jrheum.org/content/37/2/417.abstract AB Objective. To study the role of Trp64Arg polymorphism of the ADRB3 gene in the risk of developing hyperuricemia in 1051 subjects from southern Spain, with a followup of 6 years. The inclusion of plasma levels of uric acid as a diagnostic criterion to define the metabolic syndrome is under discussion. Genes responsible for insulin resistance could contribute to the development of hyperuricemia. Previous cross-sectional studies have suggested ADRB3 as a possible candidate gene in the development of hyperuricemia and insulin resistance. Methods. A prospective, population-based, cohort study of 1051 persons examined in 1997–98 and reassessed at a second examination 6 years later. The metabolic phenotype was assessed at baseline and again at the followup. Insulin resistance was measured by homeostasis model assessment. The Trp64Arg polymorphism of ADRB3 was detected by real-time polymerase chain reaction. Subjects were considered normouricemic if their serum uric acid levels were ≤7 mg/dl for men or ≤ 6 mg/dl for women. Results. Carriers of the Arg64 allele who were normouricemic at baseline had a higher risk of developing hyperuricemia 6 years later (p = 0.017, OR 2.3, 95% CI 1.1–4.6). Multivariate logistic regression analysis showed that the OR of having hyperuricemia at the 6-year followup was significantly associated with the Arg64 allele, after adjusting for age, weight gain, baseline levels of triglycerides, serum uric acid, and insulin resistance (OR 3.1, 95% CI 1.3–7.1). Conclusion. Trp64Arg polymorphism of the ADRB3 gene predicted the risk of developing hyperuricemia in this adult population.