TY - JOUR T1 - Association of the Intergenic Single-Nucleotide Polymorphism rs10865331 (2p15) with Ankylosing Spondylitis in a Spanish Population JF - The Journal of Rheumatology JO - J Rheumatol SP - 2345 LP - 2347 DO - 10.3899/jrheum.100211 VL - 37 IS - 11 AU - ALEJANDRA SÁNCHEZ AU - MAGDALENA SZCZYPIORSKA AU - XAVIER JUANOLA AU - NEREA BARTOLOMÉ AU - JORDI GRATACÓS AU - PEDRO ZARCO AU - EDUARDO COLLANTES AU - MARTA ARTIEDA AU - ANTONIO MARTÍNEZ AU - DIEGO TEJEDOR AU - JUAN MULERO Y1 - 2010/11/01 UR - http://www.jrheum.org/content/37/11/2345.abstract N2 - Objective. A recent genome-wide association study has identified 2 single-nucleotide polymorphisms (SNP) associated with ankylosing spondylitis (AS), rs10865331 (2p15) and rs2242944 (21q22). We assessed the association of these SNP with AS in a Spanish population. Methods. Four hundred fifty-six patients with AS fulfilling the modified New York Criteria and 300 healthy donors were analyzed. Result. SNP rs10865331 (allele A: p = 0.039; genotype: p = 0.016) was significantly associated with AS, while no association was found for rs2242944. Conclusion. This is the first study that replicates in an independent cohort the association of the intergenic SNP rs10865331 with susceptibility to AS. ER -