PT  - JOURNAL ARTICLE
AU  - ALEJANDRA SÁNCHEZ
AU  - MAGDALENA SZCZYPIORSKA
AU  - XAVIER JUANOLA
AU  - NEREA BARTOLOMÉ
AU  - JORDI GRATACÓS
AU  - PEDRO ZARCO
AU  - EDUARDO COLLANTES
AU  - MARTA ARTIEDA
AU  - ANTONIO MARTÍNEZ
AU  - DIEGO TEJEDOR
AU  - JUAN MULERO
TI  - Association of the Intergenic Single-Nucleotide Polymorphism rs10865331 (2p15) with Ankylosing Spondylitis in a Spanish Population
AID  - 10.3899/jrheum.100211
DP  - 2010 Nov 01
TA  - The Journal of Rheumatology
PG  - 2345--2347
VI  - 37
IP  - 11
4099  - http://www.jrheum.org/content/37/11/2345.short
4100  - http://www.jrheum.org/content/37/11/2345.full
SO  - J Rheumatol2010 Nov 01; 37
AB  - Objective. A recent genome-wide association study has identified 2 single-nucleotide polymorphisms (SNP) associated with ankylosing spondylitis (AS), rs10865331 (2p15) and rs2242944 (21q22). We assessed the association of these SNP with AS in a Spanish population. Methods. Four hundred fifty-six patients with AS fulfilling the modified New York Criteria and 300 healthy donors were analyzed. Result. SNP rs10865331 (allele A: p = 0.039; genotype: p = 0.016) was significantly associated with AS, while no association was found for rs2242944. Conclusion. This is the first study that replicates in an independent cohort the association of the intergenic SNP rs10865331 with susceptibility to AS.