PT  - JOURNAL ARTICLE
AU  - LAUNAY, DAVID
AU  - MARJANOVIC, ZORA
AU  - de BAZELAIRE, CEDRIC
AU  - FLOREA, LAURA
AU  - ZOHAR, SARAH
AU  - KESHTMAND, HOMAH
AU  - DELIGNY, CHRISTOPHE
AU  - de RAIGNIAC, AXELLE
AU  - WELLS, ATHOL U.
AU  - FARGE, DOMINIQUE
TI  - Autologous Hematopoietic Stem Cell Transplant in Systemic Sclerosis: Quantitative High Resolution Computed Tomography of the Chest Scoring
AID  - 10.3899/jrheum.081212
DP  - 2009 Jul 01
TA  - The Journal of Rheumatology
PG  - 1460--1463
VI  - 36
IP  - 7
4099  - http://www.jrheum.org/content/36/7/1460.short
4100  - http://www.jrheum.org/content/36/7/1460.full
SO  - J Rheumatol2009 Jul 01; 36
AB  - Objective. Using high resolution computed tomography (HRCT), to assess the lung involvement outcome after autologous hematopoietic stem cell transplant (AHSCT) in patients with scleroderma (systemic sclerosis, SSc). Methods. HCRT scans prospectively performed before (n = 9 patients) and after (n = 47) AHSCT were blindly reviewed by 2 independent investigators using the Wells score. Results. After a median 60 months’ followup, the overall disease extent score from HCRT scans decreased from 10 (0–45) to 4 (0–36) (p = 0.04) 6 months after AHSCT, and thereafter increased up to 36 months and stabilized; the modified Rodnan skin score fell (p < 0.05). Conclusion. The extent of SSc lung involvement on HRCT rapidly but transiently regressed after AHSCT.