TY - JOUR T1 - Fertility and Reproduction in Male Patients with Ankylosing Spondylitis Treated with Infliximab JF - The Journal of Rheumatology JO - J Rheumatol SP - 351 LP - 354 DO - 10.3899/jrheum.080554 VL - 36 IS - 2 AU - SOPHIA PASCHOU AU - PARASKEVI V. VOULGARI AU - ILEANA G. VRABIE AU - IOANNA G. SAOUGOU AU - ALEXANDROS A. DROSOS Y1 - 2009/02/01 UR - http://www.jrheum.org/content/36/2/351.abstract N2 - Objective. To identify male patients who were treated with infliximab and had fathered healthy newborns during their management. Methods. We reviewed medical records of men with ankylosing spondylitis (AS) who were followed up at the Rheumatology Outpatients clinic and were treated with infliximab during the period 2001–2007. Results. We identified 4 patients with AS who had fathered 6 healthy children during infliximab treatment. One patient was also treated with small doses of methotrexate. Conclusion. Limited data are available concerning the effects of infliximab on semen quality. Our cases provide some evidence or reassurance for male patients treated with the anti-tumor necrosis factor-α agent. Further prospective studies are necessary, however, to guide clinicians in decisionmaking. ER -