PT - JOURNAL ARTICLE AU - MICHAEL A. BECKER AU - H. RALPH SCHUMACHER AU - KATY L. BENJAMIN AU - PETER GOREVIC AU - MARIA GREENWALD AU - JEFFREY FESSEL AU - LAWRENCE EDWARDS AU - ARIANE K. KAWATA AU - LORI FRANK AU - ROYCE WALTRIP AU - ALLAN MAROLI AU - BILL HUANG AU - The Gout Natural History Study Group AU - JOHN S. SUNDY TI - Quality of Life and Disability in Patients with Treatment-Failure Gout AID - 10.3899/jrheum.071229 DP - 2009 May 01 TA - The Journal of Rheumatology PG - 1041--1048 VI - 36 IP - 5 4099 - http://www.jrheum.org/content/36/5/1041.short 4100 - http://www.jrheum.org/content/36/5/1041.full SO - J Rheumatol2009 May 01; 36 AB - Objective. The relationship between self-reported quality of life and disability and disease severity was evaluated in subjects with treatment-failure gout (n = 110) in a prospective, 52-week, observational study. Methods. Subjects had symptomatic crystal-proven gout of at least 2 years’ duration and intolerance or refractoriness to conventional urate-lowering therapy. Serum uric acid (sUA) concentration, swollen and tender joint counts, frequency and severity of gout flares, tophus assessments, comorbidities, and patient-reported outcomes data [Medical Outcomes Study Short Form-36 (SF-36), Health Assessment Questionnaire-Damage Index] were collected. Analyses included correlations of patient-reported outcomes with clinical variables and changes in clinical status. Results. Mean age of study subjects was 59 years. Mean scores on SF-36 physical functioning subscales were 34.2–46.8, analogous to persons aged ≥ 75 years in the general population. Subjects with more severe gout at baseline had worse health-related quality of life (HRQOL) in all areas (p < 0.02 for all measures), compared to patients with mild-moderate disease. Number of flares reported in past year, number of tender joints, swollen joints, and tophi correlated significantly with some or all HRQOL and disability measures. sUA was not significantly correlated with any HRQOL or disability measure. Subjects with comorbidities experienced worse physical, but not mental, functioning. Conclusion. Severe gout is associated with poor HRQOL and disability, especially for patients who experience more gout flares and have a greater number of involved joints. Subject perceptions of gout-related functioning and pain severity appear to be highly sensitive indicators of HRQOL and disability.