@article {JACOBSEN731, author = {S{\O}REN JACOBSEN and PETER GARRED and HANS OLE MADSEN and NIELS H.H. HEEGAARD and MERETE LUND HETLAND and KRISTIAN STENGAARD-PEDERSEN and PETER JUNKER and TINE LOTTENBURGER and TORKEL ELLINGSEN and LIS SMEDEGAARD ANDERSEN and IB HANSEN and HENRIK SKJ{\O}DT and JENS KRISTIAN PEDERSEN and ULRIK BIRK LAURIDSEN and ANDERS J. SVENDSEN and ULRIK TARP and JAN P{\O}DENPHANT and HANNE LINDEGAARD and AAGE VESTERGAARD and MIKKEL {\O}STERGAARD and KIM H{\O}RSLEV-PETERSEN}, title = {Mannose-Binding Lectin Gene Polymorphisms Are Associated with Disease Activity and Physical Disability in Untreated, Anti-Cyclic Citrullinated Peptide-Positive Patients with Early Rheumatoid Arthritis}, volume = {36}, number = {4}, pages = {731--735}, year = {2009}, doi = {10.3899/jrheum.080846}, publisher = {The Journal of Rheumatology}, abstract = {Objective. To study the association between polymorphisms in the mannose-binding lectin gene (MBL2) and disease activity, physical disability, and joint erosions in patients with newly diagnosed rheumatoid arthritis (RA). Methods. Patients with early RA (n = 158) not previously treated with disease modifying antirheumatic drugs, participating in a treatment trial (CIMESTRA study) were examined at inclusion for MBL2 pooled structural genotypes (O/O, A/O, A/A), regulatory MBL2 promoter polymorphism in position -221 (XX, XY, YY), anti-cyclic citrullinated peptide 2 antibodies (anti-CCP2), disease activity by Disease Activity Score-28 (DAS28 score), physical disability by Health Assessment Questionnaire (HAQ) score, and erosive changes in hands and feet (Sharp-van der Heijde score). Results. Eight patients were homozygous MBL2 defective (O/O), 101 belonged to an intermediate group, and 49 were MBL2 high producers (YA/YA). Anti-CCP was present in 93 patients (59\%). High scores of disease activity, C-reactive protein-based DAS28 (p = 0.02), and physical disability by HAQ (p = 0.01) were associated with high MBL2 expression genotypes in a gene-dose dependent way, but only in anti-CCP-positive patients. At this early stage of the disease there was no association with erosion score from radiographs. Conclusion. The results point to a synovitis-enhancing effect of MBL in anti-CCP-positive RA, whereas such an effect was not demonstrated for joint erosions.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/36/4/731}, eprint = {https://www.jrheum.org/content/36/4/731.full.pdf}, journal = {The Journal of Rheumatology} }