RT Journal Article
SR Electronic
T1 The Influence of Sex on Patients with Rheumatoid Arthritis in a Large Observational Cohort
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 508
OP 511
DO 10.3899/jrheum.080724
VO 36
IS 3
A1 IIKUNI, NORIKO
A1 SATO, ERI
A1 HOSHI, MASAYA
A1 INOUE, EISUKE
A1 TANIGUCHI, ATSUO
A1 HARA, MASAKO
A1 TOMATSU, TAISUKE
A1 KAMATANI, NAOYUKI
A1 YAMANAKA, HISASHI
YR 2009
UL http://www.jrheum.org/content/36/3/508.abstract
AB Objective. To compare the sex differences of various components of rheumatoid arthritis (RA). Methods. Data of 4823 patients from a large observational cohort study were analyzed. Remarkable differences were noted between the sexes, and overall, women had significantly higher disease activity. Results. When variables were adjusted using sex, age, and duration, Health Assessment Questionnaire, rather than Disease Activity Score, contributed most to sex difference. Further analysis showed evidence that progression of disability was approximately 3 times more rapid in female patients compared to male patients. Conclusion. Women overall have higher RA disease activity and are prone to greater and faster progression of disability over time.