RT Journal Article
SR Electronic
T1 Vitamin C Intake and Serum Uric Acid Concentration in Men
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1853
OP 1858
VO 35
IS 9
A1 XIANG GAO
A1 GARY CURHAN
A1 JOHN P. FORMAN
A1 ALBERTO ASCHERIO
A1 HYON K. CHOI
YR 2008
UL http://www.jrheum.org/content/35/9/1853.abstract
AB Objective We examined associations between vitamin C intake and serum uric acid in men in a population-based study. Methods We included 1387 men without hypertension and with body mass index (BMI) < 30 kg/m2 in the Health Professional Follow-up Study. Dietary intake was assessed with a semiquantitative food frequency questionnaire validated for use in this population. Serum uric acid concentrations were measured. Results Greater intakes of total vitamin C were significantly associated with lower serum uric acid concentrations, after adjustment for smoking, BMI, ethnicity, blood pressure, presence of gout, use of aspirin, and intake of energy, alcohol, dairy protein, fructose, meat, seafood and coffee. An inverse dose-response association was observed through vitamin C intake of 400–500 mg/day, and then reached a plateau. Adjusted mean uric acid concentrations across total vitamin C intake categories (< 90, 90–249, 250–499, 500–999, or ≥ 1000 mg/day) were 6.4, 6.1, 6.0, 5.7, and 5.7 mg/dl, respectively (p for trend < 0.001). Greater vitamin C intake was associated with lower prevalence of hyperuricemia (serum uric acid > 6 mg/dl). Multivariate odds ratios for hyperuricemia across total vitamin C intake categories were 1 (reference), 0.58, 0.57, 0.38, and 0.34 (95% CI 0.20–0.58; P for trend < 0.001). When we used dietary data, which were assessed 4–8 years before blood collection, as predictors, we observed similar inverse associations between vitamin C intake and uric acid. Conclusion These population-based data indicate that vitamin C intake in men is inversely associated with serum uric acid concentrations. These findings support a potential role of vitamin C in the prevention of hyperuricemia and gout.