TY - JOUR T1 - Soluble Endothelial Cell Adhesion Molecules and Their Relationship to Disease Activity in Takayasu’s Arteritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1842 LP - 1845 VL - 35 IS - 9 AU - NARESH K. TRIPATHY AU - VINOD CHANDRAN AU - NAVEEN K. GARG AU - NAKUL SINHA AU - SONIYA NITYANAND Y1 - 2008/09/01 UR - http://www.jrheum.org/content/35/9/1842.abstract N2 - Objective To investigate soluble (s) E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1), and their relationship to disease activity in Takayasu’s arteritis (TA). Methods Levels of adhesion molecules were measured by enzyme immunoassay in the sera of 35 patients with TA, 17 healthy controls, and 15 patients with 12 months followup. Results Compared to controls, patients had elevated levels of sE-selectin (54.5 ± 35.0 vs 36.4 ± 13.0 ng/ml, p < 0.05), sVCAM-1 (280.9 ± 267.6 vs 141.2 ± 76.1 ng/ml, p < 0.05), and sICAM-1 (261.3 ± 168.1 vs 198.3 ± 74.3 ng/ml, p < 0.05). Compared to controls, patients with inactive TA also had elevated levels of sE-selectin (67.4 ± 45.9 vs 36.4 ± 13.0 ng/ml, p < 0.02), sVCAM-1 (327.6 ± 327.8 vs 141.2 ± 76.1 ng/ml, p < 0.02), and sICAM-1 (321.9 ± 179.5 vs 198.3 ± 74.3 ng/ml, p < 0.02). There was no difference between active TA and controls. sE-selectin had a trend towards increased levels in inactive versus active TA (67.4 ± 45.9 vs 44.9 ± 20.3 ng/ml p = 0.059), but there was no difference in sVCAM-1 and sICAM-1 levels between the groups. No adhesion molecule levels showed a change among followup patients. Conclusion Patients with inactive TA have elevated levels of sE-selectin, sVCAM-1, and sICAM-1 that might indicate persistent vasculopathy in clinically inactive disease. ER -