RT Journal Article
SR Electronic
T1 No Association Between Systemic Sclerosis and C77G Polymorphism in the Human PTPRC (CD45) Gene
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1817
OP 1819
VO 35
IS 9
A1 HOLGER KIRSTEN
A1 MECHTHILD BLUME
A1 FRANK EMMRICH
A1 NICO HUNZELMANN
A1 RUDOLF MIERAU
A1 RITA RZEPKA
A1 PETER VAITH
A1 TORSTEN WITTE
A1 INGA MELCHERS
A1 PETER AHNERT
YR 2008
UL http://www.jrheum.org/content/35/9/1817.abstract
AB Objective The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort. Methods We genotyped 171 cases and 179 controls. Cases were subgrouped according to sex, autoantibody profiles, or clinical subsets. Results No association of SSc with C77G was detected in the whole dataset, in subgroups, or in combined analyses with a previous study. Conclusion The results do not confirm PTPRC C77G as a general and independent risk factor for development of SSc.