RT Journal Article
SR Electronic
T1 Subclinical atherosclerosis in psoriatic arthritis: a case-control study.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 877
OP 882
VO 35
IS 5
A1 Eder, Lihi
A1 Zisman, Devy
A1 Barzilai, Menashe
A1 Laor, Arie
A1 Rahat, Michal
A1 Rozenbaum, Michael
A1 Bitterman, Haim
A1 Feld, Joy
A1 Rimar, Doron
A1 Rosner, Itzhak
YR 2008
UL http://www.jrheum.org/content/35/5/877.abstract
AB OBJECTIVE: To investigate the prevalence of subclinical atherosclerosis among patients with psoriatic arthritis (PsA). METHODS: Forty patients with PsA were enrolled. Controls were matched by age, sex, and atherosclerotic risk factors. All patients and controls underwent duplex scan of the carotid arteries. Carotid intima-media thickness (IMT) was evaluated and the presence of atherosclerotic plaques was recorded. The plaques were graded and carotid plaque index was calculated. RESULTS: Patients with PsA had a higher IMT (mean +/- standard deviation, 1.04 +/- 0.35 mm vs 0.88 +/- 0.29 mm in controls; p = 0.03), and had a higher carotid plaque index than did matched controls (2.3 +/- 2.6, compared to 1.12 +/- 2.09; p = 0.03). Multivariate analysis demonstrated that PsA status as well as age and triglyceride levels were associated with the presence of carotid plaque. Other traditional risk factors were more prevalent among patients with PsA; however, they were not statistically significant. CONCLUSION: Our study demonstrates that patients with PsA may have an increased prevalence of subclinical atherosclerosis. These findings may not be solely attributable to traditional risk factors alone. Special attention and strict control of atherosclerotic risk factors in patients with PsA is warranted.