RT Journal Article SR Electronic T1 Bone Scanning of Limited Value for Diagnosis of Symptomatic Oligofocal and Multifocal Osteonecrosis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1629 OP 1634 VO 35 IS 8 A1 MICHAEL A. MONT A1 SLIF D. ULRICH A1 THORSTEN M. SEYLER A1 JONATHAN M. SMITH A1 DAVID R. MARKER A1 MIKE S. McGRATH A1 DAVID S. HUNGERFORD A1 LYNNE C. JONES YR 2008 UL http://www.jrheum.org/content/35/8/1629.abstract AB Objective Bone scintigraphy has been advocated as a useful diagnostic tool for patients with suspected osteonecrosis or in screening for multifocal disease. We evaluated the sensitivity of bone scanning relative to magnetic resonance imaging (MRI) in the diagnosis of osteonecrosis. Methods Forty-eight patients presented with suspected osteonecrosis of the shoulder, hip, knee, or ankle. All patients underwent simultaneous (< 3 months apart) bone scans and MRI studies as part of diagnostic investigations. Histological confirmation of osteonecrosis was obtained for all suspected lesions. The diagnostic result for each imaging modality was then assessed and compared. Results All 163 (100%) histologically confirmed lesions were identified by MRI, while only 91 lesions (56%) were identified by bone scan. There was complete congruency of bone scans with MR images in only 38% of patients (18/48). Bone scanning identified 72% of lesions (47/65) in oligofocal patients (≤2 joints involved) compared with 45% of the lesions (44/98) in multifocal patients (≥3 joints involved). Sensitivity of lesions was highest for the knee and hip and lower for the shoulder and ankle. Larger and later-stage lesions had a higher bone scan sensitivity. Conclusion Our results demonstrated the low sensitivity of bone scintigraphy for diagnosing symptomatic osteonecrosis. It is least sensitive for early-stage lesions where it might be most useful to diagnose the disease. Our study also confirms that this test is less sensitive for joints other than the hip and is also not useful as a screening tool. Our study does not support the use of bone scans as a diagnostic or screening tool for osteonecrosis.