TY - JOUR T1 - <em>Toll-like Receptor 4</em> and <em>CD14</em> Polymorphisms in Ankylosing Spondylitis: Evidence of a Weak Association in Finns JF - The Journal of Rheumatology JO - J Rheumatol SP - 1609 LP - 1612 VL - 35 IS - 8 AU - JENNIFER J. POINTON AU - KAY CHAPMAN AU - DAVID HARVEY AU - ANNE-MARIE SIMS AU - LINDA BRADBURY AU - KARI LAIHO AU - MARKKU KAUPPI AU - KALEVI KAARELA AU - JAAKKO TUOMILEHTO AU - MATTHEW A. BROWN AU - B. PAUL WORDSWORTH Y1 - 2008/08/01 UR - http://www.jrheum.org/content/35/8/1609.abstract N2 - Objective To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). Methods A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. Results In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. Conclusion CD14 and TLR4 showed an association with AS in the Finns only. ER -