RT Journal Article
SR Electronic
T1 Alendronate-induced synovitis.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 537
OP 538
VO 35
IS 3
A1 David P Gwynne Jones
A1 Ruth L Savage
A1 John Highton
YR 2008
UL http://www.jrheum.org/content/35/3/537.abstract
AB We describe 7 cases of synovitis or arthritis occurring after commencement of alendronate for treatment of osteoporosis. These were cases from our practice or notified to the New Zealand Pharmacovigilance Centre, Dunedin, New Zealand. There was no evidence of rheumatoid arthritis, pyrophosphate arthropathy, or seronegative arthritis in any patient. Symptoms recurred on rechallenge in 5 of the cases. We conclude alendronate should be considered as a possible cause of synovitis or polyarthritis in patients treated with it in the absence of any other pathology.