RT Journal Article
SR Electronic
T1 Genetics of Psoriasis and Psoriatic Arthritis: Update and Future Direction
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1449
OP 1453
VO 35
IS 7
A1 KRISTINA CALLIS DUFFIN
A1 VINOD CHANDRAN
A1 DAFNA D. GLADMAN
A1 GERALD G. KRUEGER
A1 JAMES T. ELDER
A1 PROTON RAHMAN
YR 2008
UL http://www.jrheum.org/content/35/7/1449.abstract
AB Psoriasis and psoriatic arthritis (PsA) both have substantive genetic determinants. Numerous candidate regions and genes have now been replicated in disease susceptibility, and to a lesser extent in disease expression, in both disease entities. Intensive efforts are now under way or are being planned to perform genome-wide association scans (GWAS) in psoriasis and PsA. A major determinant of success for GWAS is likely to be accumulation of multiple large well-phenotyped cohorts, sophisticated data management, and verification of the findings. At the 2007 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members of the GRAPPA genetics committee presented a discussion of the genetics of psoriasis and PsA, including future trends. This article is a summary of that presentation and a review of the literature.