PT  - JOURNAL ARTICLE
AU  - SWAN S. YEAP
AU  - AHMAD R. FAUZI
AU  - NORELLA C.T. KONG
AU  - ABDUL G. HALIM
AU  - ZAINUDIN SOEHARDY
AU  - ISMAIL RAHIMAH
AU  - SOOK K. CHOW
AU  - EMILY M.L. GOH
TI  - A Comparison of Calcium, Calcitriol, and Alendronate in Corticosteroid-Treated Premenopausal Patients with Systemic Lupus Erythematosus
AID  - 10.3899/jrheum.080634
DP  - 2008 Dec 01
TA  - The Journal of Rheumatology
PG  - 2344--2347
VI  - 35
IP  - 12
4099  - http://www.jrheum.org/content/35/12/2344.short
4100  - http://www.jrheum.org/content/35/12/2344.full
SO  - J Rheumatol2008 Dec 01; 35
AB  - Objective To assess bone mineral density (BMD) changes in patients with systemic lupus erythematosus (SLE) undergoing longterm therapy with corticosteroids (CS) while taking calcium, calcitriol, or alendronate. The primary endpoint was BMD changes at 2 years. Methods Premenopausal SLE patients were randomized into 3 groups according to medication: calcium carbonate 500 mg bd (calcium alone), calcitriol 0.25 μg bd plus calcium carbonate 500 mg bd (calcitriol + calcium), and alendronate 70 mg/week plus calcium carbonate 500 mg bd (alendronate + calcium). BMD was measured at baseline and at the end of the first and second years. Results Ninety-eight patients were recruited. There were 33 patients taking calcium alone, 33 calcitriol + calcium, and 32 alendronate + calcium. On randomization, median duration of CS use was 2.5 years (range 0–20 yrs). Seventy-seven patients (78.6%) completed the study (23 taking calcium alone, 27 calcitriol + calcium, 27 alendronate + calcium). There were no significant differences in mean CS dosages among the 3 groups at the time of BMD measurements. After 2 years, there were no significant changes in BMD in the calcium-alone and calcitriol + calcium groups, apart from a 0.93% (p < 0.001) reduction in total hip BMD in the calcium-alone group. In contrast, the alendronate + calcium group showed significant increases in BMD of 2.69% (p < 0.001) in the lumbar spine and 1.41% (p < 0.001) in total hip. Conclusion Both calcium alone and calcitriol + calcium preserved lumbar spine BMD in premenopausal patients with SLE taking longterm CS at 2 years, whereas alendronate + calcium led to increases in BMD in lumbar spine and total hip. Premenopausal women taking CS should be considered for osteoporosis prophylaxis.