PT  - JOURNAL ARTICLE
AU  - Gisele Zandman-Goddard
AU  - Michal Solomon
AU  - Aviv Barzilai
AU  - Yehuda Shoenfeld
TI  - Lupus erythematosus tumidus induced by sex reassignment surgery.
DP  - 2007 Sep 01
TA  - The Journal of Rheumatology
PG  - 1938--1940
VI  - 34
IP  - 9
4099  - http://www.jrheum.org/content/34/9/1938.short
4100  - http://www.jrheum.org/content/34/9/1938.full
SO  - J Rheumatol2007 Sep 01; 34
AB  - OBJECTIVE: We describe a case of sex reassignment surgery and the subsequent development of lupus erythematosus tumidus (LET). LET is characterized clinically by erythematous, succulent, edematous, nonscarring plaques in sun-exposed areas. Results of histological examination show perivascular and periadnexal lymphocytic infiltration and interstitial mucin deposition. This report emphasizes that environmental triggers, including prolonged exposure to significant doses of estrogens as part of sex reassignment surgery, may lead to the development of lupus in a nonpredisposed individual.